Glyoxylic acid
Glyoxylic acid
CAS: 298-12-4
Molecular Formula: C2H2O3
Glyoxylic acid - Names and Identifiers
| Name | Glyoxylic acid |
| Synonyms | GA oxoacetate Glyoxalate glyoxylate oxo-aceticaci GLYOXALIC ACID Glyoxylic acid GLYOXYLIC ACID Glyoxalic acid oxo-acetic acid Acetic acid, oxo ACETIC ACID, OXO- Aldehydoformicacid alpha-ketoaceticacid |
| CAS | 298-12-4 |
| EINECS | 206-058-5 |
| InChI | InChI=1/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 |
| InChIKey | HHLFWLYXYJOTON-UHFFFAOYSA-N |
Glyoxylic acid - Physico-chemical Properties
| Molecular Formula | C2H2O3 |
| Molar Mass | 74.04 |
| Density | 1.33g/mLat 20°C |
| Melting Point | -93°C |
| Boling Point | 111°C |
| Flash Point | 111°C |
| Water Solubility | miscible |
| Solubility | Soluble in water, the aqueous solution is yellow; it is hardly soluble in ether, ethanol and benzene. It can absorb moisture and become slurry after being exposed to air for a short time, which is corrosive. |
| Vapor Presure | 14hPa at 19.85℃ |
| Appearance | Clear Liquid |
| Color | Colorless to Light orange to Yellow |
| Merck | 14,4511 |
| BRN | 741891 |
| pKa | 3.18(at 25℃) |
| Storage Condition | Store below +30°C. |
| Refractive Index | n20/D 1.414 |
| MDL | MFCD00006958 |
| Physical and Chemical Properties | Properties the aqueous solution is a colorless transparent liquid. melting point 70~75 ℃ (hemihydrate) solubility slightly soluble in ethanol, ether and benzene. |
| Use | Used as a flavoring agent and fixative for cosmetics, for Pharmaceutical |
Glyoxylic acid - Risk and Safety
| Risk Codes | R34 - Causes burns R43 - May cause sensitization by skin contact R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S37/39 - Wear suitable gloves and eye/face protection S24 - Avoid contact with skin. |
| UN IDs | UN 3265 8/PG 2 |
| WGK Germany | 1 |
| RTECS | MD4550000 |
| TSCA | Yes |
| HS Code | 29183000 |
| Hazard Class | 8 |
| Packing Group | III |
Glyoxylic acid - Upstream Downstream Industry
| Raw Materials | Oxalic acid Nitric acid Glyoxal |
| Downstream Products | 4-Hydroxyphenylacetic acid Allantoin 2-Hydroxyphosphonoacetic Acid |
Glyoxylic acid - Reference
| Reference Show more | Zhao Guo-Qun, Wang Wei. Rapid determination of γ-aminobutyric acid by colorimetry [J]. Food research and development, 2015, 26 (10):85-89. |
Glyoxylic acid - Nature
Open Data Verified Data
The aqueous solution was a colorless transparent liquid. The melting point of the hemihydrate is 70-75 °c, and the melting point of the anhydrate is 98 °c. Soluble in water, ethanol-soluble, ether and benzene.
Last Update：2025-06-10 22:55:16
Glyoxylic acid - Preparation Method
Open Data Verified Data
- oxalic acid electrolysis oxalic acid aqueous solution is reduced by electrolysis to generate a dilute solution of glyoxylic acid, which is then gradually concentrated by evaporation, concentration, freezing and filtration, and finally a qualified product package is obtained.
- glyoxal oxidation glyoxal is oxidized by air or oxygen under the action of catalyst to generate glyoxylic acid, which is then refined and purified to obtain a finished product.
Last Update：2022-01-01 10:31:33
Glyoxylic acid - Introduction
Glyoxylic acid is a white crystal with an unpleasant smell. The aqueous solution is a colorless or light yellow transparent liquid
Last Update：2022-10-16 17:24:21
Glyoxylic acid - Application
Open Data Verified Data
is a raw material for vanillin and is used as a high-grade flavor.
Last Update：2025-08-19 16:24:40
Glyoxylic acid - Safety
Open Data Verified Data
- This product is toxic, corrosive, and can irritate the skin and mucous membranes. 40% product rat oral LD50 was 70mg/kg. Operators should pay attention to wear good labor protection products, and use a lot of water to rinse the skin.
- glass bottle or transparent plastic barrel. 2kg, 5kg, lokg, 25kg and 50kg net weight, according to the provisions of the storage and transportation of toxic chemicals.
Last Update：2022-01-01 10:31:34
Glyoxylic acid - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | glyoxylic acid (English glyoxylic acid), chemical formula C2H203, pure product is colorless crystal, melting point 93°C, soluble in water, slightly soluble in ethanol, ether and benzene, etc. |
| Biological activity | Glyoxalic acid (NSC 27785) is an organic compound that is both an aldehyde and a carboxylic acid. |
| use | glyoxylic acid is the simplest keto acid (aldehyde acid), which has the properties of both acid and aldehyde. it is used as an intermediate for varnish raw materials, spices, medicines, dyes, plastics and household chemicals. Can be used to produce oral penicillin vanillin, ethyl vanillin and allantoin (see 01320). Allantoin is an anti-ulcer drug, and it is also an intermediate of some pharmaceutical products and daily chemicals. Further processing can be made into trace high-efficiency liquid fertilizers. Used as a flavoring agent and fixating agent for cosmetics, used in pharmaceuticals Glyoxylic acid is an important fine chemical raw material, in medicine (mainly used for broad-spectrum antibiotic amoxicillin, antihypertensive drug atenolol, cosmetic additive allantoin, high value-added aromatic aldehyde, p-hydroxyphenformic acid, etc.), water quality stabilizer, perfume (ethyl vanillin), pesticide intermediates, etc. have a wide range of applications. |
| production method | 1. oxalic acid electrolysis oxalic acid aqueous solution is reduced by electrolysis to generate glyoxylic acid dilute solution, then gradually thickened by evaporation, concentration, freezing and filtration, and finally qualified product packaging is obtained. 2. Glyoxal oxidation method Glyoxal is oxidized by air or oxygen under the action of a catalyst to generate glyoxylic acid, and then refined and purified to obtain a finished product. In addition, dichloroacetic acid is condensed with sodium methoxide to obtain sodium dimethoxyacetate, which is hydrolyzed with hydrochloric acid to produce glyoxylic acid. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:08
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View History
Glyoxylic acid
410092-98-7
Cystagon
硅石
Silver Ion standard solution Fluka
Bms 540215
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4-CHLORO-3 6-PYRIDAZINEDIOL
410092-98-7
Cystagon
硅石
Silver Ion standard solution Fluka
Bms 540215
FEMA 2584
4-CHLORO-3 6-PYRIDAZINEDIOL
Raw Materials for Glyoxylic acid
Downstream Products for Glyoxylic acid